Malnutrition impairs mitochondrial function and leukocyte activation.

ABSTRACT: BACKGROUND:The aim of this study was to evaluate markers of inflammation, oxidative stress and endothelial function in a disease-related malnutrition (DRM) outpatient population. METHODS:For this cross-sectional study, a total of 83 subjects were included and clustered in 3 groups: 34 with normonutrition (NN), 21 with DRM without inflammation (DRM-I) and 28 with DRM and inflammation (DRM + I). Nutritional diagnosis was conducted for all subjects according to ASPEN. Biochemical parameters, proinflammatory cytokines, reactive oxygen species production, glutathione, mitochondrial membrane potential, oxygen consumption, adhesion molecules and leukocyte-endothelium interactions were evaluated. RESULTS:DRM + I patients showed lower albumin, prealbumin, transferrin, and retinol-binding protein le

SUBMITTER: Banuls C 

PROVIDER: S-EPMC6933906 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature