Hedgehog/GLI signaling in tumor immunity - new therapeutic opportunities and clinical implications.

ABSTRACT: Uncontrolled activation of the Hedgehog/Glioma-associated oncogene (HH/GLI) pathway is a potent oncogenic driver signal promoting numerous cancer hallmarks such as proliferation, survival, angiogenesis, metastasis and metabolic rewiring. Several HH pathway inhibitors have already been approved for medical therapy of advanced and metastatic basal cell carcinoma and acute myeloid leukemia with partially impressive therapeutic activity. However, de novo and acquired resistance as well as severe side effects and unexplained lack of therapeutic efficacy are major challenges that urgently call for improved treatment options with more durable responses. The recent breakthroughs in cancer immunotherapy have changed our current understanding of targeted therapy and opened up promising therapeutic o

SUBMITTER: Grund-Groschke S 

PROVIDER: S-EPMC6933925 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature