Dataset Information

High occurrence of transportation and logistics occupations among vascular dementia patients: an observational study.

ABSTRACT: BACKGROUND:Growing evidence suggests a role of occupation in the emergence and manifestation of dementia. Occupations are often defined by complexity level, although working environments and activities differ in several other important ways. We aimed to capture the multi-faceted nature of occupation through its measurement as a qualitative (instead of a quantitative) variable and explored its relationship with different types of dementia. METHODS:We collected occupational information of 2121 dementia patients with various suspected etiologies from the Amsterdam Dementia Cohort (age 67?±?8, 57% male; MMSE 21?±?5). Our final sample included individuals with Alzheimer's disease (AD) dementia (n?=?1467), frontotemporal dementia (n?=?281), vascular dementia (n?=?98), Lewy body disease (n?=?174), and progressive supranuclear palsy/corticobasal degeneration (n?=?101). Within the AD group, we used neuropsychological data to further characterize patients by clinical phenotypes. All participants were categorized into 1 of 11 occupational classes, across which we evaluated the distribution of dementia (sub)types with ?2 analyses. We gained further insight into occupation-dementia relationships through post hoc logistic regressions that included various demographic and health characteristics as explanatory variables. RESULTS:There were significant differences in the distribution of dementia types across occupation groups (?2?=?85.87, p?

SUBMITTER: van Loenhoud AC

PROVIDER: S-EPMC6933928 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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High occurrence of transportation and logistics occupations among vascular dementia patients: an observational study.

van Loenhoud A C AC de Boer C C Wols K K Pijnenburg Y A YA Lemstra A W AW Bouwman F H FH Prins N D ND Scheltens P P Ossenkoppele R R van der Flier W M WM

Alzheimer's research & therapy 20191227 1

<h4>Background</h4>Growing evidence suggests a role of occupation in the emergence and manifestation of dementia. Occupations are often defined by complexity level, although working environments and activities differ in several other important ways. We aimed to capture the multi-faceted nature of occupation through its measurement as a qualitative (instead of a quantitative) variable and explored its relationship with different types of dementia.<h4>Methods</h4>We collected occupational informat ...[more]

PMID: 31882022

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Project description:ObjectiveTo investigate the association between long term residential exposure to road traffic and railway noise and risk of incident dementia.DesignNationwide prospective register based cohort study.SettingDenmark.Participants1 938 994 adults aged ≥60 years living in Denmark between 1 January 2004 and 31 December 2017.Main outcome measuresIncident cases of all cause dementia and dementia subtypes (Alzheimer's disease, vascular dementia, and Parkinson's disease related dementia), identified from national hospital and prescription registries.ResultsThe study population included 103 500 participants with incident dementia, and of those, 31 219 received a diagnosis of Alzheimer's disease, 8664 of vascular dementia, and 2192 of Parkinson's disease related dementia. Using Cox regression models, 10 year mean exposure to road traffic and railway noise at the most (Ldenmax) and least (Ldenmin) exposed façades of buildings were associated with a higher risk of all cause dementia. These associations showed a general pattern of higher hazard ratios with higher noise exposure, but with a levelling off or even small declines in risk at higher noise levels. In subtype analyses, both road traffic noise and railway noise were associated with a higher risk of Alzheimer's disease, with hazard ratios of 1.16 (95% confidence interval 1.11 to 1.22) for road Ldenmax ≥65 dB compared with <45 dB, 1.27 (1.22 to 1.34) for road Ldenmin ≥55 dB compared with <40 dB, 1.16 (1.10 to 1.23) for railway Ldenmax ≥60 dB compared with <40 dB, and 1.24 (1.17 to 1.30) for railway Ldenmin ≥50 dB compared with <40 dB. Road traffic, but not railway, noise was associated with an increased risk of vascular dementia. Results indicated associations between road traffic Ldenmin and Parkinson's disease related dementia.ConclusionsThis nationwide cohort study found transportation noise to be associated with a higher risk of all cause dementia and dementia subtypes, especially Alzheimer's disease.

Dataset Information

High occurrence of transportation and logistics occupations among vascular dementia patients: an observational study.

Publications

High occurrence of transportation and logistics occupations among vascular dementia patients: an observational study.

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