Structural Insights Into TDP-43 and Effects of Post-translational Modifications.

ABSTRACT: Transactive response DNA binding protein (TDP-43) is a key player in neurodegenerative diseases. In this review, we have gathered and presented structural information on the different regions of TDP-43 with high resolution structures available. A thorough understanding of TDP-43 structure, effect of modifications, aggregation and sites of localization is necessary as we develop therapeutic strategies targeting TDP-43 for neurodegenerative diseases. We discuss how different domains as well as post-translational modification may influence TDP-43 overall structure, aggregation and droplet formation. The primary aim of the review is to utilize structural insights as we develop an understanding of the deleterious behavior of TDP-43 and highlight locations of established and proposed post-transl

SUBMITTER: Francois-Moutal L 

PROVIDER: S-EPMC6934062 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature