Cortical Circuit Dynamics Are Homeostatically Tuned to Criticality In Vivo.

ABSTRACT: Homeostatic mechanisms stabilize neuronal activity in vivo, but whether this process gives rise to balanced network dynamics is unknown. Here, we continuously monitored the statistics of network spiking in visual cortical circuits in freely behaving rats for 9 days. Under control conditions in light and dark, networks were robustly organized around criticality, a regime that maximizes information capacity and transmission. When input was perturbed by visual deprivation, network criticality was severely disrupted and subsequently restored to criticality over 48 h. Unexpectedly, the recovery of excitatory dynamics preceded homeostatic plasticity of firing rates by >30 h. We utilized model investigations to manipulate firing rate homeostasis in a cell-type-specific manner at the onset of visu

SUBMITTER: Ma Z 

PROVIDER: S-EPMC6934140 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature