Irbesartan in Marfan syndrome (AIMS): a double-blind, placebo-controlled randomised trial.

ABSTRACT:

Background

Irbesartan, a long acting selective angiotensin-1 receptor inhibitor, in Marfan syndrome might reduce aortic dilatation, which is associated with dissection and rupture. We aimed to determine the effects of irbesartan on the rate of aortic dilatation in children and adults with Marfan syndrome.

Methods

We did a placebo-controlled, double-blind randomised trial at 22 centres in the UK. Individuals aged 6-40 years with clinically confirmed Marfan syndrome were eligible for inclusion. Study participants were all given 75 mg open label irbesartan once daily, then randomly assigned to 150 mg of irbesartan (increased to 300 mg as tolerated) or matching placebo. Aortic diameter was measured by echocardiography at baseline and then annually. All images were analysed by a

SUBMITTER: Mullen M 

PROVIDER: S-EPMC6934233 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature