Quantitative MRI Biomarkers of Stereotactic Radiotherapy Outcome in Brain Metastasis.

ABSTRACT: About 20-40% of cancer patients develop brain metastases, causing significant morbidity and mortality. Stereotactic radiation treatment is an established option that delivers high dose radiation to the target while sparing the surrounding normal tissue. However, up to 20% of metastatic brain tumours progress despite stereotactic treatment, and it can take months before it is evident on follow-up imaging. An early predictor of radiation therapy outcome in terms of tumour local failure (LF) is crucial, and can facilitate treatment adjustments or allow for early salvage treatment. In this study, an MR-based radiomics framework was proposed to derive and investigate quantitative MRI (qMRI) biomarkers for the outcome of LF in brain metastasis patients treated with hypo-fractionated stereotactic

SUBMITTER: Karami E 

PROVIDER: S-EPMC6934477 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature