Increase in bone metabolic markers and circulating osteoblast-lineage cells after orthognathic surgery.

ABSTRACT: Increased mineralisation rate and bone formation after surgery or fracture is the regional acceleratory phenomenon (RAP), and its systemic impact is the systemic acceleratory phenomenon (SAP). The proportion of circulating osteoblast lineage cells, including osteocalcin-positive (OCN⁺) cells, in the peripheral blood is markedly higher during pubertal growth and in patients with bone fractures. This study aimed to elucidate the dynamic changes in bone metabolic activity after orthognathic surgery by longitudinal prospective observation. Peripheral venous blood samples were collected from patients who had undergone orthognathic surgery, and serum bone metabolic markers and the proportion of OCN⁺ cells were measured. Orthognathic surgery induces systemic dynamic changes

SUBMITTER: Abe Y 

PROVIDER: S-EPMC6934478 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature