Cholinergic Modulation Promotes Attentional Modulation in Primary Visual Cortex- A Modeling Study.

ABSTRACT: Attention greatly influences sensory neural processing by enhancing firing rates of neurons that represent the attended stimuli and by modulating their tuning properties. The cholinergic system is believed to partly mediate the attention contingent improvement of cortical processing by influencing neuronal excitability, synaptic transmission and neural network characteristics. Here, we used a biophysically based model to investigate the mechanisms by which cholinergic system influences sensory information processing in the primary visual cortex (V1) layer 4C. The physiological properties and architectures of our model were inspired by experimental data and include feed-forward input from dorsal lateral geniculate nucleus that sets up orientation preference in V1 neural responses. When incl

SUBMITTER: Sajedin A 

PROVIDER: S-EPMC6934489 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature