Neferine induces autophagy-dependent cell death in apoptosis-resistant cancers via ryanodine receptor and Ca²⁺-dependent mechanism.

ABSTRACT: Resistance of cancer cells to chemotherapy is a significant clinical concern and mechanisms regulating cell death in cancer therapy, including apoptosis, autophagy or necrosis, have been extensively investigated over the last decade. Accordingly, the identification of medicinal compounds against chemoresistant cancer cells via new mechanism of action is highly desired. Autophagy is important in inducing cell death or survival in cancer therapy. Recently, novel autophagy activators isolated from natural products were shown to induce autophagic cell death in apoptosis-resistant cancer cells in a calcium-dependent manner. Therefore, enhancement of autophagy may serve as additional therapeutic strategy against these resistant cancers. By computational docking analysis, biochemical assays, and

SUBMITTER: Law BYK 

PROVIDER: S-EPMC6934498 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature