Mesolimbic dopamine D2 receptors and neural representations of subjective value.

ABSTRACT: The process by which the value of delayed rewards is discounted varies from person to person. It has been suggested that these individual differences in subjective valuation of delayed rewards are supported by mesolimbic dopamine D2-like receptors (D2Rs) in the ventral striatum. However, no study to date has documented an association between direct measures of dopamine receptors and neural representations of subjective value in humans. Here, we examined whether individual differences in D2R availability were related to neural subjective value signals during decision making. Human participants completed a monetary delay discounting task during an fMRI scan and on a separate visit completed a PET scan with the high affinity D2R tracer [18 F]fallypride. Region-of-interest analyses revealed th

SUBMITTER: Castrellon JJ 

PROVIDER: S-EPMC6934551 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature