Intracellular Energy Variability Modulates Cellular Decision-Making Capacity.

ABSTRACT: Cells generate phenotypic diversity both during development and in response to stressful and changing environments, aiding survival. Functionally vital cell fate decisions from a range of phenotypic choices are made by regulatory networks, the dynamics of which rely on gene expression and hence depend on the cellular energy budget (and particularly ATP levels). However, despite pronounced cell-to-cell ATP differences observed across biological systems, the influence of energy availability on regulatory network dynamics is often overlooked as a cellular decision-making modulator, limiting our knowledge of how energy budgets affect cell behaviour. Here, we consider a mathematical model of a highly generalisable, ATP-dependent, decision-making regulatory network, and show that cell-to-cell AT

SUBMITTER: Kerr R 

PROVIDER: S-EPMC6934696 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature