A natural polymorphism in Zika virus NS2A protein responsible of virulence in mice.

ABSTRACT: Zika virus (ZIKV) infection is currently one of the major concerns in human public health due to its association with neurological disorders. Intensive effort has been implemented for the treatment of ZIKV, however there are not currently approved vaccines or antivirals available to combat ZIKV infection. In this sense, the identification of virulence factors associated with changes in ZIKV virulence could help to develop safe and effective countermeasures to treat ZIKV or to prevent future outbreaks. Here, we have compared the virulence of two related ZIKV strains from the recent outbreak in Brazil (2015), Rio Grande do Norte Natal (RGN) and Paraiba. In spite of both viruses being identified in the same period of time and region, significant differences in virulence and replication were o

SUBMITTER: Avila-Perez G 

PROVIDER: S-EPMC6934710 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature