Restoration of liver sinusoidal cell phenotypes by statins improves portal hypertension and histology in rats with NASH.

ABSTRACT: Non-alcoholic steatohepatitis (NASH) is a common chronic liver disorder in developed countries, with the associated clinical complications driven by portal hypertension (PH). PH may precede fibrosis development, probably due to endothelial dysfunction at early stages of the disease. Our aim was to characterize liver sinusoidal endothelial cell (LSEC) dedifferentiation/capillarization and its contribution to PH in NASH, together with assessing statins capability to revert endothelial function improving early NASH stages. Sprague-Dawley rats were fed with high fat glucose-fructose diet (HFGFD), or control diet (CD) for 8 weeks and then treated with simvastatin (sim) (10 mg·kg^-1·day^-1), atorvastatin (ato) (10 mg·kg^-1·day^-1) or vehicle during 2 weeks

SUBMITTER: Bravo M 

PROVIDER: S-EPMC6934751 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature