Dissecting multi drug resistance in head and neck cancer cells using multicellular tumor spheroids.

ABSTRACT: One of the hallmarks of cancers is their ability to develop resistance against therapeutic agents. Therefore, developing effective in vitro strategies to identify drug resistance remains of paramount importance for successful treatment. One of the ways cancer cells achieve drug resistance is through the expression of efflux pumps that actively pump drugs out of the cells. To date, several studies have investigated the potential of using 3-dimensional (3D) multicellular tumor spheroids (MCSs) to assess drug resistance; however, a unified system that uses MCSs to differentiate between multi drug resistance (MDR) and non-MDR cells does not yet exist. In the present report we describe MCSs obtained from post-diagnosed, pre-treated patient-derived (PTPD) cell lines from head and neck squamous c

SUBMITTER: Azharuddin M 

PROVIDER: S-EPMC6934860 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature