Selenium unmasks protective iron armor: A possible defense against cutaneous inflammation and cancer.

ABSTRACT: Background:A link between selenium deficiency and inflammatory skin diseases have been noted by many, but this link is still not well understood. We have previously studied the efficacy of ceramide analogs, based on the fire ant venom Solenopsin A, against our psoriasis animal model. Treatment of animals with solenopsin analogs resulted in significantly improved skin as well as in a coordinate downregulation of selenoproteins, namely Glutathione Peroxidase 4 (GPX4). We thus hypothesize that ferroptosis may be a physiologic process that may protect the skin from both inflammatory and neoplastic processes.

Methods:We analyze and compare gene expression profiles in the GEO database from clinical skin samples taken from healthy patients and psoriasis patients (both involve

SUBMITTER: Arbiser JL 

PROVIDER: S-EPMC6934939 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature