Detection of PLA2R Autoantibodies before the Diagnosis of Membranous Nephropathy.

ABSTRACT:

Background

Circulating serum autoantibodies against the M-type phospholipase A2 receptor (PLA2R-AB) are a key biomarker in the diagnosis and monitoring of primary membranous nephropathy (MN). However, little is known about the appearance and trajectory of PLA2R-AB before the clinical diagnosis of MN.

Methods

Using the Department of Defense Serum Repository, we analyzed PLA2R-AB in multiple, 1054 longitudinal serum samples collected before diagnosis of MN from 134 individuals with primary MN, 35 individuals with secondary MN, and 134 healthy volunteers. We evaluated the presence and timing of non-nephrotic range proteinuria (NNRP) and serum albumin measurements in relation to PLA2R-AB status.

Results

Analysis of PLA2R-AB in longitudinal serum samples revealed seroposit

SUBMITTER: Burbelo PD 

PROVIDER: S-EPMC6934991 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature