Early Steroid Withdrawal in Deceased-Donor Kidney Transplant Recipients with Delayed Graft Function.

ABSTRACT:

Background

Early steroid withdrawal (ESW) is associated with acceptable outcomes in kidney transplant (KT) recipients. Recipients with delayed graft function (DGF), however, often have a suboptimal allograft milieu, which may alter the risk/benefit equation for ESW. This may contribute to varying practices across transplant centers.

Methods

Using the Scientific Registry of Transplant Recipients, we studied 110,019 adult deceased-donor KT recipients between 2005 and 2017. We characterized the association of DGF with the use of ESW versus continued steroid maintenance across KT centers, and quantified the association of ESW with acute rejection, graft failure, and mortality using multivariable logistic and Cox regression with DGF-ESW interaction terms.

Results

Overall 2

SUBMITTER: Bae S 

PROVIDER: S-EPMC6934998 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature