Periostin Promotes Cell Proliferation and Macrophage Polarization to Drive Repair after AKI.

ABSTRACT:

Background

The matricellular protein periostin has been associated with CKD progression in animal models and human biopsy specimens. Periostin functions by interacting with extracellular matrix components to drive collagen fibrillogenesis and remodeling or by signaling through cell-surface integrin receptors to promote cell adhesion, migration, and proliferation. However, its role in AKI is unknown.

Methods

We used mice with conditional tubule-specific overexpression of periostin or knockout mice lacking periostin expression in the renal ischemia-reperfusion injury model, and primary cultures of isolated tubular cells in a hypoxia-reoxygenation model.

Results

Tubular epithelial cells showed strong production of periostin during the repair phase of ischemia reperfusion

SUBMITTER: Kormann R 

PROVIDER: S-EPMC6935011 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature