Hepatotoxicity and the role of the gut-liver axis in rats after oral administration of titanium dioxide nanoparticles.

ABSTRACT:

Background

Due to its excellent physicochemical properties and wide applications in consumer goods, titanium dioxide nanoparticles (TiO₂ NPs) have been increasingly exposed to the environment and the public. However, the health effects of oral exposure of TiO₂ NPs are still controversial. This study aimed to illustrate the hepatotoxicity induced by TiO₂ NPs and the underlying mechanisms. Rats were administered with TiO₂ NPs (29 nm) orally at exposure doses of 0, 2, 10, 50 mg/kg daily for 90 days. Changes in the gut microbiota and hepatic metabolomics were analyzed to explore the role of the gut-liver axis in the hepatotoxicity induced by TiO₂ NPs.

Results

TiO₂ NPs caused slight hepatotoxicity, including clear

SUBMITTER: Chen Z 

PROVIDER: S-EPMC6935065 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature