Genetic dissection of canine hip dysplasia phenotypes and osteoarthritis reveals three novel loci.

ABSTRACT:

Background

Hip dysplasia and osteoarthritis continue to be prevalent problems in veterinary and human medicine. Canine hip dysplasia is particularly problematic as it massively affects several large-sized breeds and can cause a severe impairment of the quality of life. In Finland, the complex condition is categorized to five classes from normal to severe dysplasia, but the categorization includes several sub-traits: congruity of the joint, Norberg angle, subluxation degree of the joint, shape and depth of the acetabulum, and osteoarthritis. Hip dysplasia and osteoarthritis have been proposed to have separate genetic etiologies.

Results

Using Fédération Cynologique Internationale -standardized ventrodorsal radiographs, German shepherds were rigorously phenotyped for osteoarth

SUBMITTER: Mikkola L 

PROVIDER: S-EPMC6935090 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature