Analysis of gene expression profiles and protein-protein interaction networks in multiple tissues of systemic sclerosis.

ABSTRACT:

Background

Systemic sclerosis (SSc), a multi-organ disorder, is characterized by vascular abnormalities, dysregulation of the immune system, and fibrosis. The mechanisms underlying tissue pathology in SSc have not been entirely understood. This study intended to investigate the common and tissue-specific pathways involved in different tissues of SSc patients.

Methods

An integrative gene expression analysis of ten independent microarray datasets of three tissues was conducted to identify differentially expressed genes (DEGs). DEGs were mapped to the search tool for retrieval of interacting genes (STRING) to acquire protein-protein interaction (PPI) networks. Then, functional clusters in PPI networks were determined. Enrichr, a gene list enrichment analysis tool, was utilized

SUBMITTER: Karimizadeh E 

PROVIDER: S-EPMC6935135 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature