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The effect of childhood trauma, ApoE genotype and HIV-1 viral protein R variants on change in cognitive performance.

ABSTRACT:

Objective

Gene-environment interactions contribute to the development of HIV-associated neurocognitive disorders. We examined whether childhood trauma, apolipoprotein E isoforms and viral protein R (Vpr) variants were associated with change in cognitive performance. Seventy-three seropositive women completed neuropsychological assessments at baseline and 1-year follow-up. We conducted genetic analyses using DNA obtained from blood and calculated risk scores based on Vpr amino acid 37, 41 and 55 variants that were previously associated with cognitive performance.

Results

Global cognitive scores declined significantly over the 1-year study period (p = 0.029). A reduction in global cognitive scores was associated with childhood trauma experience (p = 0.039).

SUBMITTER: Womersley JS

PROVIDER: S-EPMC6935155 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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The effect of childhood trauma, ApoE genotype and HIV-1 viral protein R variants on change in cognitive performance.

Womersley Jacqueline S JS Clauss Lara B LB Varathan Olivette O Engelbrecht Susan S Hemmings Sian M J SMJ Seedat Soraya S Spies Georgina G

BMC research notes 20191227 1

<h4>Objective</h4>Gene-environment interactions contribute to the development of HIV-associated neurocognitive disorders. We examined whether childhood trauma, apolipoprotein E isoforms and viral protein R (Vpr) variants were associated with change in cognitive performance. Seventy-three seropositive women completed neuropsychological assessments at baseline and 1-year follow-up. We conducted genetic analyses using DNA obtained from blood and calculated risk scores based on Vpr amino acid 37, 41 ...[more]

PMID: 31881924

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