Nanoharvesting of bioactive materials from living plant cultures using engineered silica nanoparticles.

ABSTRACT: Plant secondary metabolites are valuable therapeutics not readily synthesized by traditional chemistry techniques. Although their enrichment in plant cell cultures is possible following advances in biotechnology, conventional methods of recovery are destructive to the tissues. Nanoharvesting, in which nanoparticles are designed to bind and carry biomolecules out of living cells, offers continuous production of metabolites from plant cultures. Here, nanoharvesting of polyphenolic flavonoids, model plant-derived therapeutics, enriched in Solidago nemoralis hairy root cultures, is performed using engineered mesoporous silica nanoparticles (MSNPs, 165 nm diameter and 950 m²/g surface area) functionalized with both titanium dioxide (TiO₂, 425 mg/g particles) for coordinati

SUBMITTER: Khan MA 

PROVIDER: S-EPMC6935263 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature