A large pool of actively cycling progenitors orchestrates self-renewal and injury repair of an ectodermal appendage.

ABSTRACT: The classical model of tissue renewal posits that small numbers of quiescent stem cells (SCs) give rise to proliferating transit-amplifying cells before terminal differentiation. However, many organs house pools of SCs with proliferative and differentiation potentials that diverge from this template. Resolving SC identity and organization is therefore central to understanding tissue renewal. Here, using a combination of single-cell RNA sequencing (scRNA-seq), mouse genetics and tissue injury approaches, we uncover cellular hierarchies and mechanisms that underlie the maintenance and repair of the continuously growing mouse incisor. Our results reveal that, during homeostasis, a group of actively cycling epithelial progenitors generates enamel-producing ameloblasts and adjacent layers of no

SUBMITTER: Sharir A 

PROVIDER: S-EPMC6935352 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature