Phenome-wide investigation of health outcomes associated with genetic predisposition to loneliness.

ABSTRACT: Humans are social animals that experience intense suffering when they perceive a lack of social connection. Modern societies are experiencing an epidemic of loneliness. Although the experience of loneliness is universally human, some people report experiencing greater loneliness than others. Loneliness is more strongly associated with mortality than obesity, emphasizing the need to understand the nature of the relationship between loneliness and health. Although it is intuitive that circumstantial factors such as marital status and age influence loneliness, there is also compelling evidence of a genetic predisposition toward loneliness. To better understand the genetic architecture of loneliness and its relationship with associated outcomes, we extended the genome-wide association study me

SUBMITTER: Abdellaoui A 

PROVIDER: S-EPMC6935385 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature