Integrative Deep Learning for Identifying Differentially Expressed (DE) Biomarkers.

ABSTRACT: As a large amount of genetic data are accumulated, an effective analytical method and a significant interpretation are required. Recently, various methods of machine learning have emerged to process genetic data. In addition, machine learning analysis tools using statistical models have been proposed. In this study, we propose adding an integrated layer to the deep learning structure, which would enable the effective analysis of genetic data and the discovery of significant biomarkers of diseases. We conducted a simulation study in order to compare the proposed method with metalogistic regression and meta-SVM methods. The objective function with lasso penalty is used for parameter estimation, and the Youden J index is used for model comparison. The simulation results indicate that the prop

SUBMITTER: Lim J 

PROVIDER: S-EPMC6935456 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature