Ontology highlight
ABSTRACT:
SUBMITTER: Lakkadwala S
PROVIDER: S-EPMC6935563 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Nanomedicine : nanotechnology, biology, and medicine 20191025
Combination therapy has emerged as an efficient way to deliver chemotherapeutics for treatment of glioblastoma. It provides collaborative approach of targeting cancer cells by acting via multiple mechanisms, thereby reducing drug resistance. However, the presence of impermeable blood brain barrier (BBB) restricts the delivery of chemotherapeutic drugs into the brain. To overcome this limitation, we designed a dual functionalized liposomes by modifying their surface with transferrin (Tf) and a ce ...[more]