Linking genotype to phenotype to identify genetic variation relating to host susceptibility in the mountain pine beetle system.

ABSTRACT: Identifying genetic variants responsible for phenotypic variation under selective pressure has the potential to enable productive gains in natural resource conservation and management. Despite this potential, identifying adaptive candidate loci is not trivial, and linking genotype to phenotype is a major challenge in contemporary genetics. Many of the population genetic approaches commonly used to identify adaptive candidates will simultaneously detect false positives, particularly in nonmodel species, where experimental evidence is seldom provided for putative roles of the adaptive candidates identified by outlier approaches. In this study, we use outcomes from population genetics, phenotype association, and gene expression analyses as multiple lines of evidence to validate candidate gene

SUBMITTER: Cullingham CI 

PROVIDER: S-EPMC6935584 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature