Transcription closed and open complex formation coordinate expression of genes with a shared promoter region.

ABSTRACT: Many genes are spaced closely, allowing coordination without explicit control through shared regulatory elements and molecular interactions. We study the dynamics of a stochastic model of a gene-pair in a head-to-head configuration, sharing promoter elements, which accounts for the rate-limiting steps in transcription initiation. We find that only in specific regions of the parameter space of the rate-limiting steps is orderly coexpression exhibited, suggesting that successful cooperation between closely spaced genes requires the coevolution of compatible rate-limiting step configuration. The model predictions are validated using in vivo single-cell, single-RNA measurements of the dynamics of pairs of genes sharing promoter elements. Our results suggest that, in E. coli, the

SUBMITTER: Hakkinen A 

PROVIDER: S-EPMC6936044 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature