Multi-species annotation of transcriptome and chromatin structure in domesticated animals.

ABSTRACT:

Background

Comparative genomics studies are central in identifying the coding and non-coding elements associated with complex traits, and the functional annotation of genomes is a critical step to decipher the genotype-to-phenotype relationships in livestock animals. As part of the Functional Annotation of Animal Genomes (FAANG) action, the FR-AgENCODE project aimed to create reference functional maps of domesticated animals by profiling the landscape of transcription (RNA-seq), chromatin accessibility (ATAC-seq) and conformation (Hi-C) in species representing ruminants (cattle, goat), monogastrics (pig) and birds (chicken), using three target samples related to metabolism (liver) and immunity (CD4+ and CD8+ T cells).

Results

RNA-seq assays considerably extended the availabl

SUBMITTER: Foissac S 

PROVIDER: S-EPMC6936065 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature