Utilizing network pharmacology to explore the underlying mechanism of Radix Salviae in diabetic retinopathy.

ABSTRACT:

Introduction

Radix Salviae (Dan-shen in pinyin), a classic Chinese herb, has been extensively used to treat diabetic retinopathy in clinical practice in China for many years. However, the pharmacological mechanisms of Radix Salviae remain vague. The aim of this study was to decrypt the underlying mechanisms of Radix Salviae in the treatment of diabetic retinopathy using a systems pharmacology approach.

Methods

A network pharmacology-based strategy was proposed to elucidate the underlying multi-component, multi-target, and multi-pathway mode of action of Radix Salviae against diabetic retinopathy. First, we collected putative targets of Radix Salviae based on the Traditional Chinese Medicine System Pharmacology database and a network of the

SUBMITTER: Piao CL 

PROVIDER: S-EPMC6936117 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature