An ancestry informative marker panel design for individual ancestry estimation of Hispanic population using whole exome sequencing data.

ABSTRACT:

Background

Europeans and American Indians were major genetic ancestry of Hispanics in the U.S. These ancestral groups have markedly different incidence rates and outcomes in many types of cancers. Therefore, the genetic admixture may cause biased genetic association study with cancer susceptibility variants specifically in Hispanics. For example, the incidence rate of liver cancer has been shown with substantial disparity between Hispanic, Asian and non-Hispanic white populations. Currently, ancestry informative marker (AIM) panels have been widely utilized with up to a few hundred ancestry-informative single nucleotide polymorphisms (SNPs) to infer ancestry admixture. Notably, current available AIMs are predominantly located in intron and intergenic regions, while the whole exome

SUBMITTER: Wang LJ 

PROVIDER: S-EPMC6936141 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature