Functional architecture underlying binocular coordination of eye position and velocity in the larval zebrafish hindbrain.

ABSTRACT: BACKGROUND:The oculomotor integrator (OI) in the vertebrate hindbrain transforms eye velocity input into persistent position coding output, which plays a crucial role in retinal image stability. For a mechanistic understanding of the integrator function and eye position control, knowledge about the tuning of the OI and other oculomotor nuclei is needed. Zebrafish are increasingly used to study integrator function and sensorimotor circuits, yet the precise neuronal tuning to motor variables remains uncharacterized. RESULTS:Here, we recorded cellular calcium signals while evoking monocular and binocular optokinetic eye movements at different slow-phase eye velocities. Our analysis reveals the anatomical distributions of motoneurons and internuclear neurons in the nucleus abducens as well as

SUBMITTER: Brysch C 

PROVIDER: S-EPMC6936144 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature