Charting the diversity of uncultured viruses of Archaea and Bacteria.

ABSTRACT: BACKGROUND:Viruses of Archaea and Bacteria are among the most abundant and diverse biological entities on Earth. Unraveling their biodiversity has been challenging due to methodological limitations. Recent advances in culture-independent techniques, such as metagenomics, shed light on the unknown viral diversity, revealing thousands of new viral nucleotide sequences at an unprecedented scale. However, these novel sequences have not been properly classified and the evolutionary associations between them were not resolved. RESULTS:Here, we performed phylogenomic analysis of nearly 200,000 viral nucleotide sequences to establish GL-UVAB: Genomic Lineages of Uncultured Viruses of Archaea and Bacteria. The pan-genome content of the identified lineages shed light on some of their infection strat

SUBMITTER: Coutinho FH 

PROVIDER: S-EPMC6936153 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature