DNA damage in human skin and the capacities of natural compounds to modulate the bystander signalling.

ABSTRACT: Human skin is a stratified organ frequently exposed to sun-generated ultraviolet radiation (UVR), which is considered one of the major factors responsible for DNA damage. Such damage can be direct, through interactions of DNA with UV photons, or indirect, mainly through enhanced production of reactive oxygen species that introduce oxidative changes to the DNA. Oxidative stress and DNA damage also associate with profound changes at the cellular and molecular level involving several cell cycle and signal transduction factors responsible for DNA repair or irreversible changes linked to ageing. Crucially, some of these factors constitute part of the signalling known for the induction of biological changes in non-irradiated, neighbouring cells and defined as the bystander effect. Network intera

SUBMITTER: Markiewicz E 

PROVIDER: S-EPMC6936251 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature