Incorporation of a silicon-based polymer to PEG-DA templated hydrogel scaffolds for bioactivity and osteoinductivity.

ABSTRACT: A scaffold that is inherently bioactive, osteoinductive and osteoconductive may guide mesenchymal stem cells (MSCs) to regenerate bone tissue in the absence of exogenous growth factors. Previously, we established that hydrogel scaffolds formed by crosslinking methacrylated star poly(dimethylsiloxane) (PDMS_star-MA) with diacrylated poly(ethylene glycol) (PEG-DA) promote bone bonding by induction of hydroxyapatite formation ("bioactive") and promote MSC lineage progression toward osteoblast-like fate ("osteoinductive"). Herein, we have combined solvent induced phase separation (SIPS) with a fused salt template to create PDMS_star-PEG hydrogel scaffolds with controlled PDMS_star-MA distribution as well as interconnected macropores of a tunable size to allow for

SUBMITTER: Frassica MT 

PROVIDER: S-EPMC6936328 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature