Extracellular electron transfer powers flavinylated extracellular reductases in Gram-positive bacteria.

ABSTRACT: Mineral-respiring bacteria use a process called extracellular electron transfer to route their respiratory electron transport chain to insoluble electron acceptors on the exterior of the cell. We recently characterized a flavin-based extracellular electron transfer system that is present in the foodborne pathogen Listeria monocytogenes, as well as many other Gram-positive bacteria, and which highlights a more generalized role for extracellular electron transfer in microbial metabolism. Here we identify a family of putative extracellular reductases that possess a conserved posttranslational flavinylation modification. Phylogenetic analyses suggest that divergent flavinylated extracellular reductase subfamilies possess distinct and often unidentified substrate specificities. We show t

SUBMITTER: Light SH 

PROVIDER: S-EPMC6936397 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature