From bed to bench side: Reverse translation to optimize neuromodulation for mood disorders.

ABSTRACT: The advent of neuroimaging has provided foundational insights into the neural basis of psychiatric conditions, such as major depression. Across countless studies, dysfunction has been localized to distinct parts of the limbic system. Specific knowledge about affected locations has led to the development of circuit modulation therapies to correct dysfunction, notably deep brain stimulation (DBS). This and other emerging neuromodulation approaches have shown great promise, but their refinement has been slow and fundamental questions about their mechanisms of action remain. Here, we argue that their continued development requires reverse translation to animal models with close homology to humans, namely, nonhuman primates. With a particular focus on DBS approaches for depression, we highlight

SUBMITTER: Rudebeck PH 

PROVIDER: S-EPMC6936427 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature