T cell receptor specificity drives accumulation of a reparative population of regulatory T cells within acutely injured skeletal muscle.

ABSTRACT: Foxp3⁺CD4⁺ regulatory T cells (Tregs) play important roles in controlling both homeostatic processes and immune responses at the tissue and organismal levels. For example, Tregs promote muscle regeneration in acute or chronic injury models by direct effects on local muscle progenitor cells, as well as on infiltrating inflammatory cells. Muscle Tregs have a transcriptome, a T cell receptor (TCR) repertoire, and effector capabilities distinct from those of classical, lymphoid-organ Tregs, but it has proven difficult to study the provenance and functions of these unique features due to the rarity of muscle Tregs and their fragility on isolation. Here, we attempted to sidestep these hindrances by generating, characterizing, and employing a line of mice carrying rearranged

SUBMITTER: Cho J 

PROVIDER: S-EPMC6936428 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature