Patterns of postmeal insulin secretion in individuals with sulfonylurea-treated <i>KCNJ11</i> neonatal diabetes show predominance of non-K_ATP-channel pathways.

ABSTRACT:

Objective

Insulin secretion in sulfonylurea-treated KCNJ11 permanent neonatal diabetes mellitus (PNDM) is thought to be mediated predominantly through amplifying non-K_ATP-channel pathways such as incretins. Affected individuals report symptoms of postprandial hypoglycemia after eating protein/fat-rich foods. We aimed to assess the physiological response to carbohydrate and protein/fat in people with sulfonylurea-treated KCNJ11 PNDM.

Research design and methods

5 adults with sulfonylurea-treated KCNJ11 PNDM and five age, sex and body mass index-matched controls without diabetes had a high-carbohydrate and high-protein/fat meal on two separate mornings. Insulin(i) and glucose(g) were measured at baseline then regularly over 4 hours after the mea

SUBMITTER: Bowman P 

PROVIDER: S-EPMC6936449 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature