Ly49R activation receptor drives self-MHC-educated NK cell immunity against cytomegalovirus infection.

ABSTRACT: Natural killer (NK) cells mediate vital control of cancer and viral infection. They rely on MHC class I (MHC I)-specific self-receptors to identify and lyse diseased cells without harming self-MHC I-bearing host cells. NK cells bearing inhibitory self-receptors for host MHC I also undergo education, referred to as licensing, which causes them to become more responsive to stimulation via activation receptor signaling. Previous work has shown that licensed NK cells selectively expand during virus infections and they are associated with improved clinical response in human patients experiencing certain chronic virus infections, including HIV and hepatitis C virus. However, the importance of inhibitory self-receptors in NK-mediated virus immunity is debated as they also limit signals in NK cell

SUBMITTER: Gamache A 

PROVIDER: S-EPMC6936569 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature