Dataset Information
Kisspeptin treatment induces gonadotropic responses and rescues ovulation in a subset of preclinical models and women with polycystic ovary syndrome.
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ABSTRACT:
SUBMITTER: Romero-Ruiz A
PROVIDER: S-EPMC6936723 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Publications
Kisspeptin treatment induces gonadotropic responses and rescues ovulation in a subset of preclinical models and women with polycystic ovary syndrome.
Human reproduction (Oxford, England) 20191201 12
<h4>Study question</h4>Can kisspeptin treatment induce gonadotrophin responses and ovulation in preclinical models and anovulatory women with polycystic ovary syndrome (PCOS)?<h4>Summary answer</h4>Kisspeptin administration in some anovulatory preclinical models and women with PCOS can stimulate reproductive hormone secretion and ovulation, albeit with incomplete efficacy.<h4>What is known already</h4>PCOS is a prevalent, heterogeneous endocrine disorder, characterized by ovulatory dysfunction, ...[more]