Remote ischaemic conditioning and early changes in plasma creatinine as markers of one year kidney graft function-A follow-up of the CONTEXT study.

ABSTRACT:

Background

Ischaemia-reperfusion injury in kidney transplantation leads to delayed graft function (DGF), which is associated with reduced long term graft function. Remote ischaemic conditioning (RIC) improved early kidney graft function in a porcine model of donation after brain death and was associated with improved long-term cardiac outcome after myocardial ischaemia. This randomised, double-blinded trial evaluated the effect of RIC on kidney graft outcome in the first year, and examined the predictive value of a new measure of initial kidney graft function, i.e. the estimated time to a 50% reduction in plasma creatinine post-transplantation (tCr50).

Methods

A total of 225 patients undergoing deceased donor kidney transplantation were randomised to RIC or a sham procedure

SUBMITTER: Nielsen MB 

PROVIDER: S-EPMC6936785 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature