Modulation of protective reflex cough by acute immune driven inflammation of lower airways in anesthetized rabbits.

ABSTRACT: Chronic irritating cough in patients with allergic disorders may reflect behavioral or reflex response that is inappropriately matched to the stimulus present in the respiratory tract. Such dysregulated response is likely caused by sensory nerve damage driven by allergic mediators leading to cough hypersensitivity. Some indirect findings suggest that even acid-sensitive, capsaicin-insensitive A-δ fibers called "cough receptors" that are likely responsible for protective reflex cough may be modulated through immune driven inflammation. The aim of this study was to find out whether protective reflex cough is altered during acute allergic airway inflammation in rabbits sensitized to ovalbumin. In order to evaluate the effect of such inflammation exclusively on protective reflex cough, C-fiber

SUBMITTER: Foucaud L 

PROVIDER: S-EPMC6936810 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature