Sociodemographic and clinical risk factors for paediatric typical haemolytic uraemic syndrome: retrospective cohort study.

ABSTRACT:

Objectives

Haemolytic uraemic syndrome (HUS) following Shiga toxin-producing Escherichia coli (STEC) infection is the the most common cause of acute renal failure among children in the UK. This study explored differential progression from STEC to HUS by social, demographic and clinical risk factors.

Methods

We undertook a retrospective cohort study linking two datasets. We extracted data on paediatric STEC and HUS cases identified in the Public Health England National Enhanced Surveillance System for STEC and British Paediatric Surveillance Unit HUS surveillance from 1 October 2011 to 31 October 2014. Using logistic regression, we estimated the odds of HUS progression by risk factors.

Results

1059 paediatric STEC cases were included in the study, of which 207 (

SUBMITTER: Adams N 

PROVIDER: S-EPMC6936988 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature