Ontology highlight
ABSTRACT:
SUBMITTER: Wang W
PROVIDER: S-EPMC6937208 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Immunity 20191119 6
Young children are more susceptible to developing allergic asthma than adults. As neural innervation of the peripheral tissue continues to develop after birth, neurons may modulate tissue inflammation in an age-related manner. Here we showed that sympathetic nerves underwent a dopaminergic-to-adrenergic transition during post-natal development of the lung in mice and humans. Dopamine signaled through a specific dopamine receptor (DRD4) to promote T helper 2 (Th2) cell differentiation. The dopami ...[more]