In Utero Exposure to Glucocorticoids and Pubertal Timing in Sons and Daughters.

ABSTRACT: Early pubertal timing has been associated with adult diseases, and identifying preventable causes is of importance. In utero exposure to exogenous glucocorticoids, has been associated with changes in the reproductive hormonal axes in the children, which may influence pubertal timing. Exogenous glucocorticoids can be indicated for diseases such as asthma, allergy, skin diseases, as well as muscle and joint diseases. The aim was to explore the association between in utero exposure to glucocorticoids and pubertal timing in the children. This population-based study was conducted in the Puberty Cohort including 15,819 children, which is a sub-cohort of the Danish National Birth Cohort. Information on maternal glucocorticoid treatment was collected through interviews during pregnancy. Informatio

SUBMITTER: Sand SA 

PROVIDER: S-EPMC6937234 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature