RORγt⁺ Treg to Th17 ratios correlate with susceptibility to Giardia infection.

ABSTRACT: Infections with Giardia are among the most common causes of food and water-borne diarrheal disease worldwide. Here, we investigated Th17, Treg and IgA responses, and alterations in gut microbiota in two mouse lines with varying susceptibility to Giardia muris infection. Infected BALB/c mice shed significantly more cysts compared with C57BL/6 mice. Impaired control of infection in BALB/c mice was associated with lower Th17 activity and lower IgA levels compared with C57BL/6 mice. The limited metabolic activity, proliferation and cytokine production of Th17 cells in BALB/c mice was associated with higher proportions of intestinal Foxp3⁺RORγt⁺ regulatory T cells and BALB/c mice developed increased RORγt⁺ Treg:Th17 ratios in response to G. muris infection. Furt

SUBMITTER: Yordanova IA 

PROVIDER: S-EPMC6937251 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature