Integrative Analysis of Axolotl Gene Expression Data from Regenerative and Wound Healing Limb Tissues.

ABSTRACT: Axolotl (Ambystoma mexicanum) is a urodele amphibian endowed with remarkable regenerative capacities manifested in scarless wound healing and restoration of amputated limbs, which makes it a powerful experimental model for regenerative biology and medicine. Previous studies have utilized microarrays and RNA-Seq technologies for detecting differentially expressed (DE) genes in different phases of the axolotl limb regeneration. However, sufficient consistency may be lacking due to statistical limitations arising from intra-laboratory analyses. This study aims to bridge such gaps by performing an integrative analysis of publicly available microarray and RNA-Seq data from axolotl limb samples having comparable study designs using the "merging" method. A total of 351 genes were found DE in rege

SUBMITTER: Sibai M 

PROVIDER: S-EPMC6937273 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature